Mathematical modeling of histone modifications reveals the formation mechanism and function of bivalent chromatin

Summary: Bivalent chromatin is characterized by occupation of both activating and repressive histone modifications.Here, we develop a mathematical model that involves antagonistic histone modifications H3K4me3 and H3K27me3 to capture the The Mobile Phone Affinity Scale: Enhancement and Refinement key features of bivalent chromatin.Three necessary c

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Constructing a Regional Ionospheric TEC Model in China with Empirical Orthogonal Function and Dense GNSS Observation

Using Global Navigation Satellite Systems (GNSS) observation data for developing a high-precision ionospheric Total Electron Content (TEC) model is one of the essential subjects in ionospheric physics research and the application of satellite navigation correction.In this study, we integrate the Empirical Orthogonal Function (EOF) method with The M

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